Abstract: In order to investigate the effects of foliar spraying of selenium rich water-soluble fertilizer on rice yield and selenium content, the experiment was conducted in Yinma Town, Juancheng County, and the effects of different foliar spraying schemes of selenium rich water-soluble fertilizer on rice yield and selenium content were investigated. The results showed that foliar spraying of selenium rich water-soluble fertilizer can significantly improve the growth status of rice, including plant height, panicle length, tiller number, grain number per panicle, and seed setting rate, with an increase of 11.96%, 9.11%, 7.16%, 6.27%, and 5.98%, respectively,providing effective support for improving rice yield. Meanwhile, foliar spraying of selenium rich water-soluble fertilizer significantly increased rice yield and selenium content. Treatment group D performed the best in terms of 100 grain quality and yield, with increases of 15.41% and 22.84%, respectively. Foliar spraying of selenium rich water-soluble fertilizer has a significant promoting effect on rice production, providing a feasible fertilization method for agricultural production and has broad application prospects.