Abstract: Taking E’ai No.2 Huaniu Apple orchard as the research object, the fruit tree development and apple quality of the orchard were recorded and analyzed by applying water-soluble fertilizer+organic fertilizer, diammonium hydrogen phosphate+organic fertilizer and common compound fertilizer solution, and the effects of different fertilization methods on apple growth were discussed. The results showed that the water-soluble fertilizer and ammonium dihydrogen phosphate aqueous solution combined with organic fertilizer had positive effects on the growth, yield and quality of E’ai No. 2 tree, among which the water-soluble fertilizer solution with 21-21-21 ratio of nitrogen, phosphorus and potassium combined with organic fertilizer had the best effects on the growth and fruit quality of E’ai No.2 tree.