Abstract: Under the background of large-scale and high-density cattle breeding, respiratory diseases, parasitic diseases, obstetrical diseases, gastrointestinal diseases and other diseases show a high incidence trend, which poses a great threat to the health of cattle,but also affects the stable development of cattle breeding industry, which is not conducive to the steady growth of livestock economy.Therefore, large-scale cattle farms should improve the awareness of disease prevention and control, improve the technical measures of disease prevention and control, effectively reduce the probability of various diseases, and ensure the stable operation and development of large-scale cattle farms. Based on this, the epidemic characteristics of large-scale cattle farm disease were analyzed, and the key points of comprehensive prevention and control of large-scale cattle farm disease were discussed.