Abstract: After treatment, Fasciola hepatica migrated in the liver, abdominal cavity and intestine of sheep, causing mechanical damage and chemical side marks to tissues and organs, forming hemorrhagic and inflammatory symptoms. The clinical manifestations are acute stage, chronic stage and latent stage, and a few asymptomatic sheep with worms are also infectious. In clinical diagnosis,makes differential diagnosis on the symptoms of different disease stages and pay attention to symptomatic treatment. The etiology,epidemiology, clinical symptoms, diagnosis and treatment of fasciola hepatica are discussed in this paper. Through a case of Fasciola hepatica, analyzes the diagnosis and treatment strategies of improving Fasciola hepatica. The purpose is to provide some references for the diagnosis of Fasciola hepatica in sheep.