Abstract: In order to study the effect of fertilizer reduction combined with organic fertilizer on potato production efficiency, the differences of soil nutrients, potato yield and economic efficiency were studied by setting 4 organic fertilizer treatments compared with conventional fertilization. The results showed that a certain amount of organic fertilizer could significantly increase the content of soil alkali-hydrolytic nitrogen, available phosphorus and available potassium. The potato yield of T1treatment was significantly higher than that of CK treatment, and the economic benefit of conventional fertilizer treatment was higher than that of combined organic fertilizer treatment. Therefore, conventional fertilization is still the best plan to obtain the maximum economic benefits for potatoes at this stage, fertilizer reduction combined with organic fertilizer has obvious effect on improving soil fertility, and the application of farm fertilizer combined with chemical fertilizer can also obtain ideal benefits, which is a necessary trend to promote sustainable development.