Abstract: This paper reviewed fermented herbal medicines in terms of their ability to enhance efficacy, reduce toxicity, secrete active substances and fermentation by different microbial strains and different fermentation methods. The applications and progress of fermented herbal medicines in the reuse of drug residues, feed additives and livestock and poultry disease control are introduced. It also predicts the shortage of strain screening, fermentation process standard, scale up of industry and scientific theoretical basis of fermented herbal medicines in the fermentation process. With the combination of modern microbiology, Chinese medicine and other disciplines, a more standard and mature fermentation process is further explored to make the medicinal value and application prospect of fermented herbal medicines reach great potential.