Abstract: In order to evaluate the control effect of the new compound pesticide Hexaconazole and Bupirimate fungicide and four traditional fungicides on cucumber powdery mildew in the context of resistance of cucumber powdery mildew, 30% Hexaconazole and Bupirimate ME and four traditional fungicides such as 25% Bupirimate ME（pyrimidine）, 50% Carbendazim WP（benzimidazole）,250 g/L Azoxystrobin SC（Strobilurin）, 10% Hexaconazole SC（triazole） were selected, and the sprayed by conventional spraying method to test the efficacy in the greenhouse. The results showed that the five fungicides had a good control effect on cucumber powdery mildew at the appropriate concentration. The control effects were 77.63%, 74.27%, 66.70%, 74.81% and 71.81%, respectively.The control effect of the 30% Hexaconazole and Bupirimate ME is higher than that of the other four traditional agents. It can be used as an alternative agent in some areas where powdery mildew has developed fungicide resistance.