Abstract: In order to further improve the yield and economic benefits of maize in agricultural production, taking Guangxi as an example, this paper focuses on the effects of different treatments on the yield and benefits of maize when applying high calcium and magnesium fertilizer under the condition of acid cultivated land, mainly including four test methods, namely, conventional fertilization scheme and 600 kg/hm~2, 900 kg/hm~2 and 1 200 kg/hm~2 of high calcium and magnesium fertilizer. The results showed that the yield and benefit of maize were the best when 900 kg/hm~2 high calcium and magnesium fertilizer was applied.