Abstract: In order to effectively improve the yield and quality of maize, and reduce the harm caused by Ostrinia nubilalis, this paper took the Ostrinia nubilalis in Heze area of Shandong Province as the research object, through the observation and statistics of the harm of Ostrinia nubilalis in this area, and compared the control effect of different chemicals on the harm of Ostrinia nubilalis. The results showed that two generations of Ostrinia nubilalis occurred in this area in one year. The loss rate of damaged plant, the loss rate of live worm, the loss rate of wormhole and the control effect of 10% metaverine beetle hydrazine suspension were the best,which were 92.03%, 93.15%, 89.77% and 91.65%, respectively, which were significantly higher than other agents. The worst control effect was 30% fluron indocarb suspension, and the final control effect was only 83.63%, which was significantly lower than other agents. Through the correlation analysis of different control indicators, it was found that the different indicators were positively correlated with each other, among which the decrease rate of Ostrinia nubilalis was significantly correlated with the control effect（P＜0.05）. This paper provided theoretical basis for the occurrence and control of maize pests and diseases.