Abstract: In order to investigate the effect of different drug combinations on the prevention and control of Begonia evansiana rust disease, Begonia evansiana affected by rust disease was studied, and the continuous effect of different drug combinations was analyzed and compared. The results showed that: on the 5th day after the combination of different agents and 40% compound carbendazol wettable powder, the 3 000 times liquid of 30% hexazolol emulsion had the best control effect on sick Begonia evansiana, and the plaque regression rate was 83.56%, which was significantly higher than other agents. The best prevention and control effect was achieved when the mixture of 30% hexazolol cream was 1 500 times liquid, and the plaque regression rate was 95.01%. After 30days of administration, the plaque regression rate was investigated again for sick Begonia evansiana, and it was found that the efficacy of the combination of 25% nitridazole cream was the longest, and the plaque regression rate of 1 500 times liquid was 98.15%, at3 000 times the liquid reached 91.06%.