Abstract: To study the effect of micro-nano bubbles to aeration in water on the clogging of emitters during drip irrigation with reclaimed water, four different types of irrigators were selected. Two treatment methods of reclaimed water with non-aeration and reclaimed water with aeration were set in expe-riment. The average flow rate discharge ratio variation（Dra） was used to express the development degree of emitter clogging, the Christensen uniformity coefficient（Cu） and statistical uniformity coefficient（Us） were used to evaluate the uniformity of drip irrigation system. The results show that micro-nano aeration has a very significant impact on the clogging of emitters in the reclaimed water drip irrigation system. Compared with the non-aeration treatment, the Dra values of the four emitters（E1, E2, E3, E4） are increased by 16.2%, 24.4%, 18.2% and 22.1%, respectively. The Cu and Us values of all emitters after aeration treatment are also much larger than those of emitters without aeration treatment. There are also certain differences in the control effect of aeration on the clogging of different emitters. Therefore, micro-nano aeration can reduce the risk of clogging emitters, delay the clogging degree, extend the service life of emitters and have a positive impact on the uniformity of the whole drip irrigation system. The experiment results can provide some technical support for the promotion and application of reclaimed water drip irrigation and aerated drip irrigation technology.