Abstract: In order to explore the effect of water-fertilizer-air-heat coupling on the photosynthesis index and yield of wolfberry, four-factors three-level orthogonal design method combined with range analysis and variance analysis was used. The coupling of soil water, fertilizer, air and heat had certain effects on the yield, water use efficiency and photosynthesis of wolfberry. The comprehensive adjustment measures of soil water, fertilizer, air and heat have positive effects on the yield and photosynthesis of wolfberry. Under the conditions of rainfall of 135.1 mm during the growth period of wolfberry, sandy loam soil and drip irrigation, the determined optimal combination of soil water, fertilizer, air and heat suitable for local wolfberry is A₁B₁C₁D₁. The soil is deeply ploughed to adjust the aeration, the irrigation quota is 4 815 m~3/hm~2, and top dressing amount is high fertilizer（pure nitrogen amount 1 395 kg/hm~2, pure phosphorus amount 360 kg/hm~2, pure potassium amount 270 kg/hm~2）, and PP non-woven fabric is covered to increase temperature and suppress grass. Under the optimal combination, the yield can reach 9 281.55 kg/hm~2, which is an increase of 25.37% compared with the control. At the same time, the photosynthesis of wolfberry plants is strong and the fruit quality is better. This conclusion provides a theoretical basis for the efficient utilization of water, fertilizer, air, and heat in wolfberry soil and the improvement of quality and efficiency.