Abstract: In order to evaluate the high-temperature oxidation behavior of GH4169 alloy under in-ser-vice conditions, the high-temperature oxidation behavior tests of GH4169 alloy under different processes were carried out, for which the different processes carried out were laser shock peening, heat treatment, and combined laser shock peening and heat treatment processes. The morphology of GH4169 alloy under the different treatment conditions was analyzed by a transmission electron microscope（TEM）, and the oxide composition was characterized by X-ray diffraction（XRD）. The surface morphology, cross-sectional morphology, and oxidation product composition of the samples were analyzed by scanning electron microscopy（SEM） and X-ray energy dispersive spectroscopy（EDS）. The results show that high density of dislocations and grain refinement can be induced after laser shock peening, which can accelerate the formation of oxide film in the initial stage of oxidation. After compounding with heat treatment, the precipitation phases of the alloy are generated. These precipitation phases play an important role in inhibiting the generation of needle-like spinels during the oxidation process, resulting in a more continuous and dense oxide film under the composite process. Finally, the oxidation kinetic curves were combined to reveal the growth mechanism of the oxide film after the combined treatment of laser impact strengthening and heat treatment.