Abstract: Aiming at the ecological environment of low temperature and little sunshine, severe spring drought, continuous rain in the later stage and poor soil in western Guizhou, the creation and hybrid breeding of new maize germplasms with early maturity, barren tolerance, low temperature and rain tolerance, good disease resistance and fast grain dehydration were carried out. Using the theory of "two-way selection and combination of two groups", QB 1018（female parent） and QB 2232（male parent） were used to combine a new maize variety Jinyu 2208（Qian Shenyu 20200033） with multi-resistance and high yield which was suitable for Bijie City, and Liupanshui City in Guizhou Province where planted in maize production areas with an altitude of 1 400—2 200 meters in medium and upper fertile soils. This variety could be used for seed production in the north and effectively solves temperature and light reaction problems of tropical germplasm seed production.