Abstract: In order to study the extraction technology of lutein from marigold, this study used northeast marigold as raw material to extract lutein from marigold by ultra-high pressure method and optimized the extraction technology. The single factor experiment and response surface were used to investigate the effects of four different extraction methods, such as solid-liquid ratio, extraction times, holding time and extraction pressure, on the extraction yield of lutein from marigold. Finally, the optimal extraction conditions were obtained as follows: the solid-liquid ratio was 1∶95.21（g/mL）, the extraction times was 4 times, the pressure holding time was 3 min, and the extraction pressure was 200 MPa. Under these conditions, the experiment was repeated for three times. The actual extraction yield of lutein was（ 68.57±2.31）mg/g, which was consistent with the predicted value of 69.38 mg/g. Compared with thermal reflux extraction and microwave-ultrasonic extraction, the extraction rate of lutein from marigold could be significantly improved by ultrahigh pressure extraction. The results showed that the ultra-high pressure extraction of lutein from marigold was stable, reliable and reproducible, and could be widely used.