Abstract: To break through the limitations of two-dimensional plane in the optimization of highway route design in cold regions, a new framework is proposed that effectively combines the spatial data analysis of GIS with the 3D visualization function of BIM to achieve 3D route design optimization. This paper relies on the cold zone freeway He-Yi, firstly obtaining high precision geographic data model through GIS data collection and normalization processing, then integrating it into the BIM platform to obtain 3D geographic information model, and finally using BIM technology for sub-regional route selection application to achieve scientific and efficient cold zone route planning. The research results show that the deep excavation roadbed and tunnel models generated by using GIS geographic data and BIM technology are compared and analyzed from both safety and economic aspects of the scheme, and the comprehensive results are consistent with the designer’s opinion. The comparison with the simulation results of water tank experiments verifies that BIM technology can evaluate the rationality of different schemes of water-related projects through flood simulation analysis. The traffic simulation analysis of complex intersections using this framework and the traffic data obtained can provide reference data for the determination of road construction indexes. The research on the application of GIS+BIM information technology to the three-dimensional design of He-Yi freeway route can form exemplary results to provide reference for the optimization of the subsequent cold region project selection.