Abstract: The development of composite materials with good acoustic vibration performance is an effective way to alleviate the shortage of wood resources for musical instrument soundboards. To explore the possibility of wood-plastic composite materials applied in musical instrument soundboards, the mechanical properties preparation method of composite materials was used as a reference to study the influence of wood powder content and compatibilizer content on the acoustic vibration performance parameters（specific dynamic elastic modulus, sound radiation quality constant, acoustic impedance, logarithmic decay rate） of composite materials, and comparison with traditional wood for musical instrument soundboards to determine wood powder and compatibilizer content with superior acoustic vibration properties. The research results showed that the wood powder content had a great influence on the acoustic vibration performance of wood-plastic composites. When the wood powder content increased from 60% to 80%, the acoustic vibration parameters acoustic impedance ω, logarithmic decay rate δ, specific dynamic elastic modulus value of E/ρ increased, and the vibration effect decreased slightly. In the preparation of wood-plastic composite materials, the content of compatibilizer had a great influence on the sound quality of the composite material. When 65% wood powder content was used, the content of compatibilizer accounted for 7% of wood powder content to prepare the composite, a relatively good overall performance of acoustic vibration can be obtained. Compared with the existing soundboard materials for musical instruments, the ω value（2.21 Pa·s/m） of the wood-plastic composite material in the experiment was close to that of American spruce（2.20 Pa·s/m）, and the δ was smaller than that of the wood-carbon fiber composite soundboard, but there was also a problem that the sound radiation quality constant R was smaller than that of the wood-glass fiber composite soundboard, and the specific dynamic elastic modulus was relatively small, follow-up research on this issue should be carried out.