Abstract: In order to improve the utilization rate of iron tailings and reduce the cost of grouting materials, the method of replacing river sand and fly ash with iron tailings sand and partially replacing cement with activated iron tailings powder was selected for the test. Using orthogonal test method, factors such as water cement ratio, cement sand ratio, tailings powder, and fly ash content were studied. Research showed that the influence of four factors on the strength of grouting materials was ranked in descending order: water cement ratio, tailings powder, fly ash, and cement sand ratio. Through range analysis, the optimal factor level combination for 28 days was determined to be a water cement ratio of 0.36, a cement sand ratio of 1∶0.6, a tailings powder content of 10%, and a fly ash content of 6%. Through contrast tests, the feasibility of completely replacing river sand and fly ash with iron tailings sand and partially replacing cement with activated iron tailings powder was clarified. Through X-ray diffraction（XRD） and scanning electron microscope（SEM） analysis, it was found that under the test conditions, the performance of grouting materials was improved by the production of tricalcium silicate, ettringite and other hydration products during the hydration and hardening process of grouting materials. Incomplete crack and hydration reaction would reduce the strength of grouting material.