Abstract: The prestress loss along the curve anchor cable is the key factor affecting the stress distribution of lining structure, and it is particularly important to obtain the friction coefficient and deviation coefficient. The prestress loss along the curve anchor cable under different loading states is analyzed, the model test platform is established, the non-graded, graded and graded cyclic loading tests are carried out, the stress characteristics of the anchor end and tensioning end, the variation law of prestress loss, the values of friction coefficient and deviation coefficient are analyzed, and the stress value at any point of the curve anchor cable is calculated in combination with the actual project. The results show that the friction coefficient and deviation coefficient along the curve anchor cable are not only related to the properties of the material itself, but also affected by the mechanical loading state. Compared with non-graded loading, the average prestress loss of graded loading curve anchor cable is reduced from 8.47% to 3.63%, and sufficient dead time must be given for all levels of load to maintain prestress transmission. The loss of prestress along the way of graded cyclic loading curve anchor cable is greatly reduced, but the loading time is long, so it is not suitable to be used as a conventional loading method but an emergency disposal scheme when the prestress value of very few curves anchor cables cannot meet the standard.