Abstract: Integral exterior wall is an important part of prefabricated concrete building. In order to make the ceramsite concrete integral exterior wall containing glazed hollow beads meet the thermal and mechanical performance, numerical simulation is carried out for the exterior wall, and the thermal insulation performance, stress and deformation of the wall under the coupling action of indoor and outdoor temperature difference and wind load in summer and winter respectively are analyzed. It is found that compared with ordinary concrete integral exterior wall, ceramsite concrete integral exterior wall can block heat transfer more effectively and have better thermal insulation performance. The stress of the reinforcement is in a state of low stress, and the deformation of the wall is very small, so there is no need to consider the extrusion between walls and tensile cracking of concrete caused by deformation. With the increase of the content of glazed hollow beads, the thermal insulation performance of the integral exterior wall is gradually enhanced, and it is suggested that the content should not exceed 30% in the engineering application. The influence of the wall thickness on the thermal insulation performance is relatively small. Therefore, it is suggested that the integral exterior wall with small thickness should be given priority.