Abstract: Soil Mechanics is a main course of civil engineering. It has the characteristics of broad knowledge, abstract concepts, complicated calculations, and strong theoretical and practicality. The integration of science and education is an important way to promote the reform of curriculum teaching and improve the quality of talent training. Combining the characteristics of the soil mechanics course and teaching goals, a series of reform measures were formulated as follows.The teaching design of the soil mechanics course was optimized first, then the multilevel soil mechanics course knowledge system was constructed, at the same time the teaching content and teaching mode was constructed, and finally a second classroom platform which is based on inquiry-based learning under the full process experimental mode was proposed with multiple performance evaluation systems and other reform measures. It is expected to provide new ideas for the teaching reform and innovation of soil mechanics under the background of the integration of science and education, and effectively improve students’ innovative thinking and ability.