Abstract: The construction site of the grain silo is an artificially filled area of the original sea, which is prone to settlement. In order to ensure the safety and stability of the silo, the finite element analysis software ABAQUS was used to establish a three-dimensional finite element calculation model to analyze the influence of different stages of loads and adjacent silos on the vertical bearing deformation characteristics of the silo group pile foundation. The analysis results show that the uneven distribution of vertical bearing deformation of the group pile foundation is greatly affected by the upper load. During the construction completion stage, the self-weight load of the structure mainly acts on the outer edge, and the vertical bearing deformation of the edge pile is larger, with the minimum and maximum settlement values of 0.551 mm and 0.959 mm, respectively. During the service stage, the load distribution of the full silo is relatively uniform, and the vertical bearing deformation of the center pile is larger, with the minimum and maximum settlement values of 1.271 mm and 2.335 mm, respectively. The vertical bearing deformation of the group pile foundation is greatly affected by the adjacent silo. The influence on the vertical bearing deformation of the group pile foundation decreases as the distance increases, and the settlement value increases as the number of adjacent silos increases. The uneven settlement difference increases due to the asymmetrical distribution of the adjacent silo position.