Abstract: The teaching reform guided by “OBE” education concept has become a new way to improve the quality of engineering education talents in colleges under the background of engineering education accreditation. Taking the structural seismic design course as an example, in view of the new findings in the course teaching practice, Based on the concept of OBE education, this paper discusses the teaching reform from three aspects: teaching content, teaching mode and teaching methods. Combined with the characteristics of the course, the modular design of teaching content is carried out, and the online teaching platform is used. To explore the multi-integration of online and offline mixed teaching mode, a case teaching material library oriented by practice teaching was established, and the “case teaching + project-driven” multiple integrated teaching method was developed. The whole process of assessment is realized through teaching effectiveness and multi-dimensional comprehensive performance assessment, the analysis results show that “online + offline” teaching mode and “case teaching + project-driven” multiple integrated teaching method can enhance the internal drive of students’ autonomous learning and improve their academic performance, which is very helpful to train students’ innovative thinking ability and the ability to solve complex engineering problems.