Abstract: In this study, a new method of screw extrusion coupled with ultra-low acid spray synergistic instantaneous catapult steam explosion(SCT/ULAS/ICSE) pretreatment was proposed. Bagasse, cane pith, corn stalk, corncob and wheat straw were used as research objects to investigate the pretreatment effect and energy consumption of the process. The results showed that after screw extrusion and 0.1%(volume fraction) H₂SO₄ spray treatment, the five raw materials retained 92%-94% cellulose at 160 ℃, 5 min, and 0.618 MPa steam explosion conditions. After enzymatic hydrolysis of steam explosion residue(enzyme dosage 25 FPU/g, absolute dry residue as the basis) for 72 h, the enzymatic hydrolysis yield of cellulose from bagasse(65.1%) was 44.9% higher than that of untreated raw materials. Meanwhile, the enzymatic hydrolysis yield of hemicellulose(55.6%) from corn straw increased 45.3% compared with untreated raw material. The contents of inhibitors in the hydrolysates of the five raw materials were extremely low, where the highest contents of formic acid and acetic acid were only 0.34 g/L(corn stalk) and 4.67 g/L(bagasse). The unit energy consumption of the five raw materials treated by this pretreatment process was generally similar and low, with the maximum of only 1.4 kJ/g(bagasse).