合成环氧柏木烷的新方法

A New Method of Synthesizing Epoxycedrane

摘要: 以三氯化钌和2,6-二羧基吡啶为催化剂,双氧水为氧化剂,对α-柏木烯进行环氧化反应合成环氧柏木烷。本合成方法在国内外尚未见报道。当三氯化钌的用量为1.90%,2,6-二羧基吡啶的用量为12.28%,双氧水的用量为8 倍于α-柏木烯的用量,反应时间为20 h,反应温度为23℃时,环氧柏木烷的得率最高。该方法不仅具有操作简单,反应条件温和的特点,而且实现了α-柏木烯的百分百转化,使目标产物的选择性达到84%以上。

Abstract: Epoxycedrane was firstly synthesized at home and abroad from α-cedrene by epoxidation of hydrogen peroxide under the catalysis of ruthenium trichloride and pyridine-2,6-dicarboxylic acid. The optimal conditions for synthesis of epoxycedrane were 1.90% of ruthenium trichloride,12.28% of pyridine-2,6-dicarboxylic acid, 8 times (equiv) of hydrogen peroxide, 20 h and 30℃.This method not only operates simply and reacts warmly,but also realize 100% conversion of α-cedrene and 84% selectivity of the target product.