Abstract: The preparation method of hybrid adhesive of acrylate and soy protein at home and abroad was reviewed. The major topic concerns the preparation, surface modification and application of the hybrid adhesive based on acrylate and soy protein,the hybrid adhesive based on soy protein and PF or UF. In order to get well-structured particles, surface modification of soy-protein is very important by using modifiers such as siloxane and azo compounds through the coupling modifying reaction. The application of the hybrid adhesive in the field of paints, adhesive, paper was discussed.