Abstract: Gleditsia sinensis thorn(GST) is widely distributed in China, which is commonly used in traditional Chinese medicine compatibility. However, few studies on its chemical composition and pharmacological activity hindered its further development and utilization. Based on the review of secondary metabolites containing saponins, flavonoids, triterpenoids, sterols, polyphenols, alkaloids, coumarins, indoles in GST, the research further introduced research progress of pharmacological activities of GST, such as anti-tumor, anti-bacterial, anti-oxidation, anti Human Immunodificiency Virus, anti-inflammatory, treatment of depression, treatment of prostate hyperplasia, treatment of endocrine disorders and immune regulation, providing a theoretical and application basis for the rational development and utilization of GST.