Abstract: As an important biomass-based platform compound, glycerol can be condensed with carbonyl compounds under the action of acidic catalysts to form acetals and ketals. Acetals and ketals are widely used in the fields of fuel additives, perfumes, veterinary medicine preparations, plasticizers and polyols. The catalytic performance of traditional liquid acid catalyst and solid catalyst was compared based on the synthesis mechanism of glyceryl acetal and ketal; then, the synthesis processes of several important glycerol acetals and ketals such as solketal, cyclohexanone glycerol ketal, benzaldehyde glycerol acetal, glycerol formal and glycerol levulinate ketal were introduced, and their production technology was summarized; finally, the development and application prospects of bio-based glycerol acetal and ketal are prospected.