Abstract: Cedryl acetate was synthesized from cedrol and acetic anhydride by catalysis of mixture of phosphoric acid and acetic acid under microwave irradiation. The optimum reaction condition obtained from orthogonal experiment was as follows: molar ratio of cedrol 5.55 g to acetic anhydride 1:1.5, dosage of catalyst 0.010 g, microwave irradiation power 450 W and irradiation time 20 min. Average yield of cedryl acetate was 74.6%.