Abstract: In response to the new agricultural talent training guidance and the national strategy of invigorating agriculture through science and education, Zhongkai University of Agricultural and Engineering have actively explored the innovative talent training mode of agro-industrial integration. Starting from the background of professional construction, this paper constructs the innovative talent training mode of agro-industrial integration based on mechanical engineering and agricultural engineering, including the construction of curriculum system, the construction of teacher team. The practice has proved that the model is conducive to improving students’ innovation ability and knowledge application ability under the background of new agricultural and new industrial sciences, and provides certain reference value for new agricultural science education and regional construction of agriculture.