Abstract: The establishment of a rice unmanned farm based on biotechnology, intelligent agricultural machinery,and information technology is not only an important way to accelerate the transformation of agricultural development, but also an important way to create more experience in exploring the path of modern agricultural development. In order to accelerate the construction of unmanned rice farms in Guizhou and surrounding hilly and mountainous areas, based on a brief overview of the key technologies of intelligent agricultural machinery in unmanned farms, this paper introduces the implementation and application of the Nanming unmanned farm in Jianhe County, Guizhou Province, and analyzes the constraints on the development of unmanned rice farms in hilly and mountainous areas in China and their application prospects. In order to build a demonstration base for unmanned rice production farms in hilly and mountainous areas, radiate and drive the level of modern agricultural mechanization production in surrounding areas, and provide reference for leading the national agricultural transformation and upgrading.