Abstract: A SEIAQRS infectious disease model with media coverage and isolation is established to understand the transmission mechanism of COVID-19.The existence and stability of equilibrium point are discussed by using the basic regeneration number Rc.When Rc ＜ 1,the disease-free equilibrium is globally asymptotically stable,and when Rc ＞ 1,there is a unique locally asymptotically stable endemic disease equilibrium.The effects of model parameters α（isolation rate of symptomatic infected persons）,p（recovery rate of symptomatic infected persons） and m0（media coverage coefficient） on the basic regeneration number are analyzed.It is obtained that isolating symptomatic infected persons,improving the recovery rate of symptomatic infected persons and increasing the media coverage of regular dissemination of infectious disease knowledge can reduce the basic regeneration number Rc.Finally,through numerical simulation,media coverage and effective isolation can greatly reduce the number of infected people,and thus effectively control the spread of COVID-19.