Abstract: In order to gain insights into the mechanism of corona virus transmission, based on the characteristics of vaccination, the SEIR transmission dynamics model of corona virus was established by taking into account various prevention and control measures such as population flow, nucleic acid detection and personal protection. The infected persons were classified into asymptomatic, mild and severe infected persons. The next generation matrix method was used to calculate the basic regeneration number and Lyapunov function was used to analyze the stability of the equilibrium point. Through numerical simulation and sensitivity analysis, it is found that increasing the vaccination rate is helpful to reduce the number of deaths; Control of floating populations and nucleic acid testing are both helpful in reducing the number of deaths and controlling the spread of the epidemic. Low vaccination rates will not reduce the number of asymptomatic infections, but they can reduce the total number of infections and deaths.