Abstract: 5,5′-bitet-razole-1,1′-dioxydihydroxylamine（TKX-50） was widely used and studied as a new nitrogen-rich energetic compound. In order to study the characteristics and thermal safety of its decomposition reaction, the autocatalytic characteristics of TKX-50 were studied by linear temperature rise method, isothermal method and interrupted regression method in this paper. At the same time, adiabatic induction period and the self-accelerating decomposition temperature of TKX-50 under linear temperature rise and interrupted regression were predicted by thermal analysis dynamics software AKTS. The results show that TKX-50 has the characteristics of autocatalytic decomposition in the thermal decomposition process. Once it has thermal history, it will reduce its adiabatic induction period and self-accelerating decomposition temperature, also increase the risk of explosion. The results provide a necessary theoretical basis for evaluating the thermal safety of TKX-50 in production, storage, transportation and use.