Abstract: Flood disaster is one of the main natural disasters in Hubei province. Conducting research on the resilience of urban flood disasters in Hubei Province can accelerate the construction of resilient cities in this region and promote the sustainable and healthy development of cities. This paper takes 17 cities in Hubei Province as the research object, selects the period from 2010 to 2021 as the research period, constructs the urban flood disaster resilience evaluation index system from three dimensions, including pressure, state and response, analyzes the spatio-temporal evolution of flood disaster resilience by applying the CRITIC-Entropy Weight Method combination weighting method, and analyzes the spatial agglomeration characteristics of flood disaster resilience by using the spatial autocorrelation method. Then the driving factors are analyzed by the geographic detector model. The results indicate that: First, during the study period, the resilience index of urban flood disasters in Hubei Province showed a wave rising trend, with an increase of 34.82%, Second, The spatial distribution of urban flood disaster resilience is mainly “high in the west and low in the east” pattern, with values decreasing outward from Wuhan City. The spatial agglomeration effect of urban flood disaster resilience is strong. Third, the spatial heterogeneity of urban flood disaster resilience is caused by multiple factors. Wherein, population exposure, terrain fluctuation, surface steepness and medical security capacity being the main driving factor. The research results can provide reference for urban flood control and disaster reduction policies.