Abstract: The synergy of water resources allocation pattern and land space pattern is the important foundation to ensure the economic and social development. In order to evaluate water resources spatial balance scientifically and reasonably, this paper calculates the four dimensions comprehensive indicators of water conservation, rigid water demand, water resources development and utilization through the methods of entropy, water load index, Equilibrium based on theory of system of spatial balance of water resources. Based on the three zones such as Pearl River Delta,the Coastal Economic Zone and Northern Ecological Development Zone,the Dagum Gini coefficient method are used to evaluate the spatial balance of water resources in different regions of Guangdong Province. The research findings show that the spatial balance of water resources in different regions of Guangdong Province is mainly due to inter-regional differences. The water resources spatial equilibrium of the Pearl River Delta and the Coastal Economic Zone are relatively poor, the water resources allocation are mainly from the water transfer projects. The water resources spatial equilibrium of the Northern Ecological Development Zone are well balanced, and the water resources allocation is mainly based on the local water resources utilization, which can be used as water sources for other regions. The Dagum Gini coefficient method can provide a reasonable description of differences within and between zones and the contribution of hypervariable density, and can be used as a means of evaluating the spatial equilibrium of water resources. It can provide a basis and direction for optimizing water resource allocation, and it can provide a forceful water security guarantee for improving the coordinated development of regional economy and society.