Abstract: With the continuous advancement of urbanization, the contradiction between supply and demand of water resources has been escalating, and the water resources problem has become increasingly prominent, which has seriously restricted the healthy development of regional economy. Therefore, the quantitative evaluation of ecological carrying state of water resources can provide a scientific basis for the sustainable development of the region. Collecting the data of economy, population and water resources in Southeast Sichuan from 2005 to 2019, based on the model of water resource ecological footprint, the sustainable index of water resources in southeast Sichuan is calculated by analyzing and discussing its spatio-temporal variation characteristics. The results show that:（1） From 2005 to 2019, the overall trend of ecological footprint of water resources per-capita increased first and then decreased; the ecological carrying capacity of water resources fluctuated greatly, and its change trajectory was closely related to precipitation; the amount of water resources was ecological surplus, and water resources were in a state of sustainable development, which could satisfy the needs of current social and economic development.（2） From 2005to 2019, the water resources ecological footprint of 108 yuan of GDP decreased year by year, indicating that the regional water resource utilization efficiency gradually improved; the water resources load index was between grade Ⅱ and Ⅲ, indicating that the development and utilization degree of regional water resources was high, and there was no need to transfer water across the region; the sustainable index of water resources was between 0.7 and 0.9 all the year round, and the sustainable state was medium sustainable and strong sustainable.（3） From 2015 to 2019, there were spatial differences in water resources of ecological footprint, ecological carrying capacity and ecological profit and loss among prefecture-level cities. Leshan and Meishan were relatively rich in water resources, and there was a good coordination between economic development and water resources utilization; the ecological profit and loss of water resources in Luzhou and Yibin were in the middle-low level, and the ecological carrying capacity of water resources needed to be improved. In Zigong, Neijiang and Ziyang, the ecological carrying capacity of water resources were low, the ecological profit and loss of water resources were small and the ecological pressure of water resources were large.