Abstract: Rivers originating from the Himalaya contain a large amount of sediment, which inevitably causes erosion wear and damage to the hydropower plants, seriously decrease the life time of the turbines and operational stability of the hydropower plants. A Francis turbine runner of Jhimruk Hydropower Plant in Nepal, which has been operating at large opening for a long time, is used in this study. By combining numerical simulation and wear-resistant optimization design of the turbine runner, its performance and erosion characteristics are analyzed.The results show that the three designing schemes reduce the average erosion rate of the blades without reducing the efficiency of the turbine.By changing the flow direction on the blade surface, the vortex pattern in the passage is changed, which weakens the cross flow on the pressure side of the blade, so the erosion rate of the runner is reduced. In this research, the inlet shape conforming to the linear function（scheme II） is the best for wear resistance, by which the erosion rate is reduced by 35%. The research results provide a reference for the wear-resistant design of hydraulic turbines operating at large opening conditions.