Abstract: A three-dimensional finite element model based on an actual project is established to study anti-vibration performances of the plate-beam-column system in a pumped storage power plant. This paper studies the natural vibration characteristics of plate beams,thick plates,thick plates,side beams and the dynamic response under the pulsating pressure in the flow passage. It is found that when the boundary conditions around the plant are the same,three floor structure types,floor thickness and the small adjustment of the column section size have limited influence on their natural vibration characteristics. However,from the perspective of reducing the peak value of floor forced vibration response,when the excitation frequency in the spiral case channel is 35～45 Hz,the relatively preferred structural type is thick plate and side beam. When it is 50～60 Hz,the slab beam is better. When it is 65～75 Hz,the pure thick plate performs better,and increasing the plate thickness can reduce the vibration response. In addition,when the excitation frequency in the plant is close to the natural vibration frequency of the column,increasing the section size of the column has an obvious effect on reducing the vibration response of the column. Considering the complex vibration sources in the powerhouse of pumped storage power station,it is suggested that the anti-vibration optimization design of the powerhouse structure of pumped storage power station should be carried out by dynamic finite element method with the main objective of the number frequency of runner blades and its double frequency.