Abstract: The periodic fluctuations of the reservoir water level and the complex geological conditions of the reservoir bank slope in hydraulic engineering have caused frequent occurrence of geological disasters of reservoir bank landslides. In order to study the influence of the rate of rise and fall of the reservoir water level and the mechanical parameters of rock and soil on the stability of the bank slope,this paper takes Shanmei Reservoir as the research object. Based on the analytical solution calculation of the unsteady seepage infiltration line of Boussinesq,the three-dimensional slope stability calculation model Scoops 3 D is used to calculate the bank slope stability. According to the calculation and comparison of multiple working conditions,the slope stability of the reservoir bank decreases with the increase in the reservoir water level decline rate,and a larger reservoir water level rise rate is beneficial to the stability of the reservoir bank slope. The degree of influence of rock and soil mechanical parameters on the stability of reservoir bank slopes in descending order is internal friction angle,soil weight and cohesion.