Abstract: In order to improve hydraulic performance and ensure stable operation of Zhuji Pumping Station,an optimization design of the inlet conduit and outlet conduit is completed based on three-dimensional turbulent flow numerical simulation. The experimental research on the hydrodynamic characteristics of optimized pump system model is carried out on a high-precision hydraulic machinery test bed. The experimental results show that the flow velocity of the inlet and outlet conduit of Zhuji Station changes uniformly and the hydraulic loss of the conduit is small,the highest efficiency of the pump system model is 78.33%,and the hydraulic performance is excellent. Compared with the pump section,the optimal operation point of the pump system model is offset by about 2° to the negative angle and the small flow area. Secondly,when the inlet pressure of the pump system model is equal to the value of critical net positive suction head,the larger zones of cavitation bubbles are observed on the pressure side and suction side of the blades. Thirdly,the shaft frequency and blade passing frequency have greater influence on the pressure pulsation amplitude at the inlet and outlet of impeller,and they have less influence on pressure pulsation amplitude at the outlet of the guide vane. In order to avoid resonances,the natural frequency of the pump structure should avoid the pump shaft frequency,blade passing frequency and its frequency multiplication.