Abstract: By using the principle of bionics, this paper treats the front, middle and rear parts of the blade working surface with hemispherical non-smooth structure, combined with the flow field CFD and acoustic field LMS for simulation calculation. The flow field and sound field results of the design flow of a centrifugal pump are compared and analyzed. The results show that the non-smooth structure makes the frictional resistance of the blade smaller, and then effectively reduces the shear stress and turbulent kinetic energy on the blade surface, and the weakening effect is most obvious at the blade entry and exit. At the same time, the vortex strength in the impeller flow channel is significantly reduced, and the internal vortex distribution of the pump is more uniform, which can effectively reduce its turbulent pulsation intensity as a whole, stabilize the flow field and effectively reduce the flow noise. The non-smooth structure blade can effectively reduce the total sound pressure level, among which the optimal noise reduction at the impeller outlet is 3.28 dB and the noise reduction rate is 1.9%. The total sound pressure level at the diaphragm is reduced by 3.11 dB, and the noise reduction rate is 1.82%. In summary, non-smooth blades have a good noise reduction effect compared with smooth blades, and the overall noise reduction rate is about 0.81%～1.90%.