Abstract: It is one of the most effective ways to reduce pipe network leakage by controlling pipe network pressure. Traditionally, the pressure reducing valve is only applicable to the pressure management of local pipe network. In this paper, the method of real-time regulation of the pressure reducing valve and the water supply pump station is used to manage the pipe network pressure. Based on the systematic analysis of the response relationship and characteristics between the leakage amount and the node pressure, a hydraulic model of pipe network leakage is established.Taking the water supply network in CYN District of a city in North China as an example, genetic algorithm（GA）, particle swarm optimization（PSO） and whale optimization algorithm（WOA） are used to solve the case, and then the operation effects of these three algorithms are compared and analyzed. The results show that the whale optimization algorithm has better performance for solving the leakage model.