Abstract: In the traditional reservoir multi-objective optimal operation scheme decision-making,the influence of uncertainty inflow runoff is often ignored. To solve the problem,the interval number was selected as the evaluation index,and the upper and lower limits of the interval number were the maximum and minimum values obtained by the optimal calculation when the simulated inflow runoff considering the prediction error of inflow runoff was taken as the input. Based on the subjective weight of analysis method and objective weight of critical method,the game theory combination model was used to combine the comprehensive weights. The VIKOR model was modified to improve the reliability and rationality of evaluation index weight. Then this method was applied to the multi-objective operation scheme decision-making of Three Gorges reservoir. The result shows that the decision-making result is basically consistent with the actual runoff process. That indicates the rationality and practicability of the method,and provides a new way for the multi-objective operation scheme decision-making of reservoir when the inflow runoff is uncertainty.