Abstract: The structural characteristics of large vertical submersible pumps are different from vertical pumps. A series of excellent axial and mixed flow pump models has been developed in the construction of South-to-North Water Diversion Project and many large-scale pump stations in China. There is no hydraulic model for the development of vertical submersible pumps. This paper takes a large vertical submersible pumping station in China as an example. The existing hydraulic model is used for the similarity conversion of pump section characteristics,and the CFD is used to match the guide vanes that meet the structural requirements for device model test verification. The results show that the selection flow of vertical submersible pump is about 5.8% smaller and the device efficiency is about 2.66% lower by using the conventional hydraulic model. The variation trend of flow head efficiency predicted by CFD calculation is accurate. Without considering the influence of tip clearance and surface roughness,the flow rate is about two blade angles compared with the device model test,and the highest efficiency is about 3.5%. At the same time,for the large-scale development of submersible pumps,the idea of standardized vertical submersible pump section model test is proposed. The research idea of this paper provides a reference for the selection design and hydraulic model development of large vertical submersible pumps in the future.