Abstract: In order to explore the influence of the staggered impeller on the pressure fluctuation characteristics of the double entry two-stage double suction centrifugal pump, this paper uses the method of combining experiment and numerical simulation to carry out a research on the same pump with symmetrical impeller and staggered impeller as the contrast scheme, and quantifies the pressure pulsation characteristics of the suction chamber, inter-stage flow channel and volute under three typical working conditions of 0.6Q, 1.0Q and 1.2Q. The results show that:（1） in terms of external characteristics, the head and efficiency of the pump with staggered impeller are higher than those with symmetrical impeller at all working conditions, and they can be 2% and 3% higher than those at 1.0Q working condition.（2） In terms of pressure pulsation characteristics, for the suction chamber, the influence of staggered impellers on pressure pulsation is small at all working conditions, and the difference of dominant frequency amplitude is less than 2%. For the inter-stage flow channel, the staggered impeller can restrain the pressure fluctuation at all working conditions. For example, the dominant frequency amplitude at the tongue of the inter-stage flow channel can be reduced by 13.5% compared with that of the symmetrical impeller. For the volute, the staggered impeller can improve the pressure fluctuation under all working conditions. For example, the dominant frequency amplitude at the tongue of the volute can be reduced by 31.9% at most. This finding can provide a reference for the application of staggered impeller in double inlet two-stage double suction centrifugal pump.