Abstract: This article mainly describes the sloshing and impact on the medicine box caused by the irregular movement of the liquid medicine in the medicine box during the flight operation of the plant protection drone due to different types of medicine boxes and routes, as well as the steering, emergency stop, and rotation. In the case of a plant protection drone, a test bench that can simulate the detection of the sloshing of the liquid in the medicine box under the complicated working conditions of the plant protection drone was designed. The test platform utilizes the six-degree-of-freedom motion platform to load the excitation characteristics in three-dimensional space, fully simulating the working conditions of plant protection drones during flight operations, and is designed to adapt to different shape and size of medicine box loading mechanisms to ensure that the test bench can perform an experimental analysis of most medicine boxes available on the market. Finally, the anti-shake performance of the rectangular medicine box in the market was tested using the testbed.