Abstract: In view of the heavy structure and surplus strength of a garlic planter, the six-line garlic planter frame developed by our group was taken as the optimization object, and the optimization analysis was carried out to reduce the weight and vibration, based on the finite element method. Firstly, according to the original structure and the load case, the thickness of the outer plate, the side length of the front beam and the thickness of the ribs of the rear beam were selected as the three design variables. Based on the original sizes, 64 geometric models were established, respectively. Secondly, the static analysis, modal analysis, harmonic response analysis and random vibration analysis of these models were carried out to obtain the influence of the design variables on the equivalent stress, natural frequency and dynamic response, and all the curves’ equations were obtained. Finally, the genetic algorithm was used to arrive the global optimal solution. Results show that, under the premise of the static strength, the weight of the optimized frame is reduced by 27.36%, the maximum displacement of harmonic response is reduced by 3.07%, while the decrease of the maximum displacement for random vibration is small.