Abstract: Aiming at the problems of strong vibration of the whole machine and cracking of the frame, etc, by using ANSYS Workbench19.0 software, the statics and constrained modal analysis of the frame of the residual film recycling machine are carried out, the static and modal characteristics of the frame are studied, and the natural frequency, vibration mode, damping and other parameters of the frame are obtained, on this basis, the thickness of the left and right side plates of the frame, the thickness of the main connecting beam tube and the width of the auxiliary supporting beam are taken as the experimental factors by adopting the orthogonal experimental design method, the natural frequencies of the first and second order are used to optimize the structure. When the thickness of the left and right side plate of the frame is 12 mm, the thickness of the main connecting beam tube is 6 mm, and the width of the auxiliary supporting beam is 70 mm, the natural frequencies of the first and second order of the frame are 50.747 Hz and 53.557 Hz, which are not in the range of 0.833-40 Hz of the external excitation frequency, the maximum stress value after optimization is reduced by 3.295 MPa, and the maximum amplitude of 17.642 mm before optimization is reduced by 4.923 mm compared with the maximum amplitude of 12.719 mm after optimization, the frame before and after optimization meets the requirements of stiffness and strength. This study can provide theoretical reference for the design and reliability research of the frame of residual film recovery machine.