Abstract: In order to solve the challenges of unable to perform targeted spraying and poor applicability in the strip intercropping of soybean and corn, A self-propelled spray boom sprayer designed for this planting mode has been developed. This spray machine is capable of directional and height-adjustable spraying, preventing drift between rows. Firstly, based on the agricultural requirements of the new planting mode, the spraying plan is determined. Then, the specific parameters of the 4+2 planting mode in Jiangsu Province are used to determine the design of key devices for the spray machine, including the height adjustment device for the spray boom, the folding device for the spray boom, and the drift prevention device. Finally, soybean-corn strip intercropping spraying experiments are conducted at the soybean farm in Guanyun County. The prototype’s height adjustment, folding device, and drift prevention performance are tested and verified. The results show that the height adjustment and folding devices can effectively carry out chemical weed control and chemical growth regulation for corn and soybean. The drift prevention device reduces liquid droplet drift by 92.52%.